The AudioNotch Tinnitus Treatment Blog

Tinnitus refers to the condition characterized by sounds heard in the ears that develop secondary to structural alterations. The noise varies from buzzing or ringing to chirping or thumping. The intensity also varies. The sounds may be continuous or intermittent based on possible pressure changes within the ear. Some find the noise an inconvenience while others consider the sounds deafening. For persons seeking relief, studies indicate that there is a correlation between the amino acid acetylcysteine and tinnitus.

Tinnitus Causes

When exposed to high noise levels, the delicate structures within the ear undergo stress. As a result, blood flow decreases and the neurotransmitter glutamate is released in excessive amounts, which traumatizes structures at the cellular level. Free radicals circulate in the cochlea and cause toxic effects on the fine hair cells and local neurons. Subsequently, hearing loss or tinnitus occurs. Hundreds of OTC and prescription medications may cause similar consequences.

Benefit of Acetylcysteine

The body uses acetylcysteine, also known as n-acetyl-l-cysteine or NAC, to make the compound glutathione, which acts as a defense mechanism against free radicals. When ears are exposed to loud noise, gluathione levels decrease in response to counteracting the effects of free radicals. In time, gluathione levels are completely depleted. By taking a NAC supplement, the body manufactures more glutathione to help reduce auditory stress, neutralize toxins and minimize cellular damage.

Numerous studies on laboratory animals and humans demonstrate the effectiveness of acetylcysteine and tinnitus reduction. One study involved more than 350 volunteers who were provided with oral doses of the amino acid 48 hours before loud noise exposure. Subjects continued taking NAC for 10 days. A control group received a placebo. The therapy proved effective in treating auditory trauma. Studies also suggest that acetylcysteine also proves effective if taken shortly after exposure.

Other research showed that NAC also minimized damage in patients taking the antibiotics gentamicin, vancomycin and the chemotherapy medication known as cisplatin. All of these formulations are known to cause ototoxic effects. In each study, the effects of acetylcysteine and tinnitus prevention were apparent. Participants either received oral preparations or intra-auditory infusions of the amino acid with positive results.

Dosage and Side Effects

Dosages of acetylcysteine vary from one person to the next and should not be administered unless patients are under the supervision of a health care provider. Side effects are generally on the mild side and include:

• Abdominal discomfort
• Diarrhea
• Generalized fatigue
• Skin rashes

NAC is not advised in patients diagnosed with asthma, kidney or liver disease. The amino acid should also not be taken by pregnant or breastfeeding women unless directed by a physician.